منابع مشابه
Inhibition of tumor growth by ribozyme-mediated suppression of aberrant epidermal growth factor receptor gene expression.
BACKGROUND Amplification and rearrangement of the epidermal growth factor receptor (EGFR) gene is frequently associated with malignant gliomas. One type of EGFR mutation in primary gliomas results in overexpression of an aberrant EGFR messenger RNA (mRNA) that lacks sequences of exons II through VI of the human EGFR gene. We observed that the aberrantly spliced EGFR mRNA contains a ribozyme cle...
متن کاملThe Rb tumor suppressor is required for stress erythropoiesis.
The retinoblastoma tumor suppressor gene plays important roles in cell cycle control, differentiation and survival during development and is functionally inactivated in most human cancers. Early studies using gene targeting in mice suggested a critical role for pRb in erythropoiesis, while more recent experiments have suggested that many of the abnormal embryonic phenotypes in the Rb null mouse...
متن کاملMacrophages Support Splenic Erythropoiesis in 4T1 Tumor-Bearing Mice
Anemia is a common complication of cancer; a role of spleen in tumor-stress erythropoiesis has been suggested. However, the molecular mechanisms involved in the splenic erythropoiesis following tumor maintenance remain poorly understood. Here we show that tumor development blocks medullar erythropoiesis by granulocyte colony-stimulating factor (G-CSF) and then causes anemia in murine 4T1 breast...
متن کاملExtra Fructose in the Growth Medium Fuels Lipogenesis of Adipocytes
Fructose in excessive amounts exerts negative effects on insulin sensitivity, blood pressure, and liver metabolism. These adverse outcomes were attributed to its disturbances of key metabolic pathways in the liver. Recently, possible consequences of high fructose levels directly on adipocytes in vivo have been considered. We have cultured adipocytes in growth media containing 1 g/L fructose add...
متن کاملAB74. MicroRNAs fuels cancer growth through the RNAa mechanism
MicroRNAs (miRNAs) are master regulators of gene expression and have been known to be involved in cancer by acting either as tumor suppressors or oncomiRs. It is widely accepted that the miRNAs carry out their functions in the cytoplasm via targeting the 3’ UTR region of mRNAs leading to downregulation of gene expression. However, whether and how miRNAs function in the nucleus remains largely u...
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ژورنال
عنوان ژورنال: Cell Research
سال: 2018
ISSN: 1001-0602,1748-7838
DOI: 10.1038/s41422-018-0047-1